Name: 1,3-Diphenylacetone
Cas: 102-04-5
Purity: 99%
MOQ: 1KG
Directory Guidance on 1,3-Diphenylacetone
Nature and Specifications
| MF: | C15H14O |
| MW: | 210.27 |
| EINECS: | 203-000-0 |
Basic Info
Chemically, the 1,3-diphenylacetone is C6H5CH2COCH2C6H5. The molecular structure of the 1,3-diphenylacetone is composed by a ketone group (-CO-), with phenyl groups (C6H5-) connected on both sides by methylene, creating asymmetric skeleton. The presence of aromatic rings in its structure gives it ketone-like properties and unique stability and reactivity. It is a common intermediate in organic synthesis.
Physically, the 1,3-Diphenylacetone is a white or pale yellow solid. It has a melting point of 34-36, and a boiling point around 331 under standard atmospheric pressure. It is soluble in organic solvents like ethanol, ether and benzene and can be dissolved uniformly. However, its solubility with water is very low and shows obvious hydrophobicity. The properties of the compound are stable at room temperatures due to the presence in the molecule of functional groups like benzene rings and ketone groups. Under conditions of high temperatures or strong oxidation, decompositions and oxidations may occur.
Product Introduction
| Melting point | 32-34 °C(lit.) |
| Boiling point | 330 °C(lit.) |
| density | 1.04 |
| refractive index | 1.5725 (estimate) |
| FEMA | 2397 | 1,3-DIPHENYL-2-PROPANONE |
| Fp | >230 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Liquid or Crystalline Mass |
| color | Clear yellow |
| Odor | at 10.00 % in dipropylene glycol. bitter almond benzaldehyde plastic seedy |
| Odor Type | powdery |
| Water Solubility | Slightly soluble in water. |
⇒We provide high-purity chemical raw materials with clear molecular formula and precise specifications. Each batch of 1,3-Diphenylacetone products undergoes strict quality inspection to ensure stable and reliable physical and chemical properties. It adopts international standard packaging, sealed and moisture-proof, to ensure safe transportation and storage. Whether it is R&D experiments or industrial production, we can provide you with professional technical support and customized services. With rigorous technology, transparent data and stable supply, we help you efficiently complete chemical applications and innovations.
1,3-Diphenylacetone, a key organic intermediate, is used to build complex molecular structure. It has a wide range of applications and reaction mechanisms. Its reactive structure, formed by the methylene and keto groups (-CH2-), allows it to easily form an enolate ion under alkaline condition. This enables it to participate efficiently in condensation reactions. For example, under the catalysis of sodium ethoxide, it undergoes a cross-aldol condensation with benzaldehyde at 80-90degC for 2-3 hours, yielding 1,3,5-triphenylpentenone in over 75% yield. The product can be converted to polycyclic aromatics through cyclodehydrogenation, and is a precursor in the synthesis novel fluorescent materials. Condensation reactions with hydrazines produce pyrazoline-derived compounds, which are used to extract metal ions due to their excellent coordination property.
Due to its adaptable molecular structures, 1,3 diphenylacetone has been used as a synthetic base for many pharmaceutical intermediates. The Friedel Crafts reaction can modify its aromatic ring with functional groups like hydroxyls and aminos, and the keto group can then be converted into a hydroxyl group or methylene through reduction. This can control the compound’s biological activity and lipid solubility. Studies have shown that 3-phenyl-1-(4-hydroxyphenyl)acetone derivatives synthesized from it selectively inhibit cyclooxygenase (COX-2), with a half-maximal inhibitory concentration (IC50) of up to 12 mmol/L, making it a potential anti-inflammatory drug candidate. In the development of antibacterial drug, the derivatives can be combined with quinolone structure to enhance their inhibitory action against Gram-positive bacteria. This reduces the minimum inhibitory dose (MIC) down to 0.5mg/mL.
In materials science, the 1,3-Diphenylacetone has unique advantages for the preparation of polymer materials with functional properties. As a comonomer, it undergoes free radical copolymerization with methyl methacrylate (PMMA) initiated by azobisisobutyronitrile. The resulting copolymer, at a feed ratio of 1:4, has a glass-transition temperature (Tg), 15-20degC, higher than pure PMMA and a decomposition thermal temperature above 320degC. The conjugated aromatic ring is responsible for the increased molecular chain stiffness. This copolymer, when used to make coatings achieves a pencil-hardness rating of 3H with a grade one adhesion. The color difference (DE), after 1000 hours, is only 2.3, which is significantly better than conventional acrylic coatings. The ketone groups of this adhesive react with amines, forming cross-linked structures. This increases the shear strength to more than 8 MPa.
Chemical Research Field
The 1,3-diphenylacetone compound is a good model for studying the reactions of ketone compounds. In oxidation reactions, hydrogen peroxide can be used as an oxidant with sodium tungstate acting as a catalyst to selectively convert ketone groups into ester groups. The formation and transformation can be observed by tracking the changes in proton nuclear magnetic resonance (1H NMR spectrum) of the intermediate. This provides direct evidence to elucidate the nucleophilic mechanism of ketone addition. A comparison between sodium borohydride reduction mechanism and catalytic hydrogenation revealed that stereoselectivity of the former towards secondary alcohol was 3:1 while that of this latter was 1:2. This difference helps to understand the stereochemical properties in different reduction systems. The kinetics of phase transfer catalysis has also helped reveal the effect of charge transfer on reaction rates.
Related References
Manufacturer of 1,3-Diphenylacetone
Zhishang Chemical is based in Shandong, serves the whole country, faces the world, and is determined to become an excellent supplier and service provider in the chemical industry.
As a top manufacturer of cosmetic raw materials, disinfectants, flavors and fragrances in China, we are committed to producing high-quality products and have won high praise from customers all over the world.
In the next 10 years or even longer, Zhishang will always adhere to the tenet of quality first and reputation first, and devote itself to providing customers with thoughtful and perfect services.
As a professional 1,3-Diphenylacetone manufacturer, Zhi shang Chemical has served more than 6,000 customers around the world. Because of our high-quality products and professional services, we have won high praise from most of our customers.
Pre-Sales Service
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* The sample supports testing and inspection.
* Each batch of products will be tested to ensure that its quality meets user needs.
*Packaging can also be made according to customer requirements.
*Any inquiries will be answered by our relevant personnel within 24 hours.
*We will provide you with commercial invoice, packing list, packing list, COA, health certificate and certificate of origin if you need it. If your market has other special requirements, please let us know.
After-Sales Service
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*If you have any questions about the product, you can report it to us, we will deal with it in time for you, and the product can be returned.
DO YOU ACCEPT SAMPLE ORDER?
We will make samples before mass production. After the samples are approved by the department and users, we will start mass production. During the production process, we will carry out 100% inspection, and then carry out random inspection before packaging.
WHAT’S YOUR MOQ?
Our MOQ is 1kg. But usually we can also accept a smaller quantity, such as 100g, if you need it, provided that the sample fee is 100% paid.
IS THERE A DISCOUNT?
Different quantity has different discount.
HOW TO CONFIRM WHETHER THE PRODUCT QUALITY MEETS OUR NEEDS BEFORE PLACING AN ORDER?
You can consult us to get free samples of some products, you only need to pay the freight or arrange express delivery to us and get the samples. You can send us the product specifications and requirements you need, and we will manufacture products according to your requirements.
DO YOU SUPPLY PRODUCT REPORT?
Yes. We’ll give you product analysis report before shipping.
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