Name: 3-(Trifluoromethyl)cinnamic Acid
Cas: 779-89-5
Purity: 99%
MOQ: 1KG
Directory Guidance on 3-(Trifluoromethyl)cinnamic Acid
Chemical Structure
Basic Info
3-(Trifluoromethyl)cinnamic Acid is the raw material for the preparation of Cinacalcet Hydrochloride. Cinacalcet Hydrochloride, chemically known as N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]-1-propylamine hydrochloride, is an FDA-approved calcimimetic drug that has been marketed in the United States and Europe. Clinically, it is used to treat secondary hypoparathyroidism among patients on dialysis with chronic kidney disease and to lower elevated blood calcium in parathyroid cancer patients. This product has been proven effective in treating secondary hyperparathyroidism due to chronic renal disease on dialysis. It is also safe, easy to administer, and bioavailable.
Product Introduction
| Melting point | 135-137 °C(lit.) |
| Boiling point | 224°C (rough estimate) |
| density | 1.3275 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 4.25±0.10(Predicted) |
| form | Solid |
| color | White to Off-White |
| MF: | C10H7F3O2 |
| MW: | 216.16 |
| EINECS: | 212-301-6 |
| Item | Specification |
| Product Name | 3-(Trifluoromethyl)cinnamic Acid |
| CAS No. | 779-89-5 |
| Appearance | Powder |
| Shelf Life | 2 years |
| Packing | As your requirements |
Product Packaging
1. Pharmaceutical pesticide intermediates
Drug synthesis: 3- (trifluoromethyl) cinnamic acid is a key intermediate for constructing bioactive molecules containing trifluoromethyl, such as anti-inflammatory, anti-tumor, and antiviral drugs (such as certain kinase inhibitors).
Pesticide development: Trifluoromethyl has a strong electron absorption effect, which can enhance the stability and biological activity of pesticide molecules, and can be used to synthesize efficient insecticides or herbicides.
2. Organic photoelectric materials
Liquid crystal material: Its rigid structure and -CF ∝ polarity make it suitable for the synthesis of liquid crystal display (LCD) materials and improve dielectric anisotropy.
OLED intermediates: 3- (trifluoromethyl) cinnamic acid participates in the preparation of light-emitting layers or electron transport materials as conjugated main chains to improve device efficiency.
3. Polymer and functional materials
Special polymers: Fluoropolymers that are heat and chemical resistant (such as coatings and adhesives) are prepared by polymerization involving carboxyl groups and double bonds.
Metal coordination chemistry: 3- (trifluoromethyl) cinnamic acid acts as a ligand to form complexes with metal ions (e.g., palladium, copper) to catalyze coupling reactions (e.g., Suzuki reaction)
4. Food and spice industry
Flavor enhancers: Some derivatives can be used in synthetic food flavors to impart a special flavor (such as caramel or woody), but must comply with food safety regulations.
Preservative research: Cinnamic acid derivatives containing trifluoromethyl may have antibacterial activity and can be used in the development of food preservatives (further validation required).
5. Analytical Chemistry and testing
HPLC standard: 3- (trifluoromethyl) cinnamic acid is used as a standard reference for chromatographic analysis for the detection or quantification of fluorinated organic compounds.
Fluorescent labeling: Its derivatives can be used for biomolecular labeling, such as fluorescent probes of proteins or nucleic acids.
6. Surface treatment and coating
Antifouling coatings: containing fluoro groups can enhance the hydrophobicity and weather resistance of coatings, suitable for Marine antifouling or industrial anticorrosive coatings.
Uv-curable material: 3- (trifluoromethyl) cinnamic acid is used as a photosensitive monomer for the synthesis of UV-curable resins for 3D printing or electronic packaging.
7. Catalysts and additives
Organic catalysis: as a Lewis acid ligand or cocatalyst, participating in asymmetric synthesis reactions (such as Michael addition).
Battery electrolyte additives: Study of their potential to improve electrode stability in lithium-ion batteries (experimental support required).
Related References
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Manufacturer of 3-(Trifluoromethyl)cinnamic Acid
Zhishang Chemical is based in Shandong, serves the whole country, faces the world, and is determined to become an excellent supplier and service provider in the chemical industry.
As a top manufacturer of cosmetic raw materials, disinfectants, flavors and fragrances in China, we are committed to producing high-quality products and have won high praise from customers all over the world.
In the next 10 years or even longer, Zhishang will always adhere to the tenet of quality first and reputation first, and devote itself to providing customers with thoughtful and perfect services.
As a professional 3-(Trifluoromethyl)cinnamic Acid manufacturer, Zhi shang Chemical has served more than 6,000 customers around the world. Because of our high-quality products and professional services, we have won high praise from most of our customers.
Pre-Sales Service
* Timely reply and 24 hours online, the professional team will provide you with the most favorable prices and high-quality products.
* The sample supports testing and inspection.
* Each batch of products will be tested to ensure that its quality meets user needs.
*Packaging can also be made according to customer requirements.
*Any inquiries will be answered by our relevant personnel within 24 hours.
*We will provide you with commercial invoice, packing list, packing list, COA, health certificate and certificate of origin if you need it. If your market has other special requirements, please let us know.
After-Sales Service
*We will monitor the logistics information in real time and will share the information with you.
* You can consult us at any time if you have any questions about the product, and we will answer you in time.
*If you have any questions about the product, you can report it to us, we will deal with it in time for you, and the product can be returned.
DO YOU ACCEPT SAMPLE ORDER?
We will make samples before mass production. After the samples are approved by the department and users, we will start mass production. During the production process, we will carry out 100% inspection, and then carry out random inspection before packaging.
WHAT’S YOUR MOQ?
Our MOQ is 1kg. But usually we can also accept a smaller quantity, such as 100g, if you need it, provided that the sample fee is 100% paid.
IS THERE A DISCOUNT?
Different quantity has different discount.
HOW TO CONFIRM WHETHER THE PRODUCT QUALITY MEETS OUR NEEDS BEFORE PLACING AN ORDER?
You can consult us to get free samples of some products, you only need to pay the freight or arrange express delivery to us and get the samples. You can send us the product specifications and requirements you need, and we will manufacture products according to your requirements.
DO YOU SUPPLY PRODUCT REPORT?
Yes. We’ll give you product analysis report before shipping.
LEARN MORE ABOUT US
Shandong Look Chemical
1. For products ≤50kg, we recommend using express delivery, which is usually called DDU service (discounted, convenient).
2. For products ≤500kg, we generally recommend air freight, which is usually called FOB, CFR or CIF service (fast and efficient).
3. For products >500kg, we generally recommend shipping by sea, which is usually called FOB, CFR or CIF service (economical, safe).
4. For high-value products, please choose air or express to ensure the safety of product transportation.
