Cremophor EL Solubilizing Agent | CAS 61791-12-6 Wholesale Supply
Name: Cremophor EL
Cas: 61791-12-6
Purity: 99%
MOQ: 1KG
Directory Guidance on Cremophor EL
Basic Info
For pharmaceutical procurement managers, cosmetic formulation chemists, and agrochemical sourcing directors, purchasing a bulk non-ionic surfactant involves evaluating deep chemical metrics far beyond the standard price per metric ton. Because this ethoxylated triglyceride serves as a primary vehicle for poorly water-soluble compounds, precise hydroxyl values, stable Hydrophilic-Lipophilic Balance (HLB) metrics, and ultra-low residual free ethylene oxide (EO) thresholds dictate your final formulation stability.
Sourcing from unverified, low-tier chemical brokers often introduces material with erratic water content or high peroxide values. These hidden defects lead to rapid phase separation in emulsions, severe cloud point drift during thermal processing, or unwanted chemical degradation of sensitive active ingredients over product shelf life.
Our Cremophor EL (Polyoxyl 35 Castor Oil, CAS 61791-12-6) is manufactured using a highly controlled ethoxylation process of premium, cosmetic-grade natural castor oil. We guarantee a clear, high-purity viscous liquid profile (complying fully with current USP/NF and European Pharmacopoeia monographs) with exceptionally low trace moisture and heavy metal limits. This translates to predictable critical micelle concentration (CMC) kinetics, zero unexpected viscosity drift, and excellent inventory storage stability in your production facilities.
Nature
- Chemical Name: Polyoxyl 35 Castor Oil; Polyoxyethylene castor oil; Cremophor EL
- CAS Number: 61791-12-6
- Active Matter (Assay): 100% (Pure non-ionic surfactant)
- Appearance: Pale yellow, clear, oily viscous liquid at room temperature; becomes paste-like at low temperatures
- HLB Value (Hydrophilic-Lipophilic Balance): 12.0 – 14.0
- Water Content (Karl Fischer): ≤ 3.0%
- Hydroxyl Value: 60 – 80
- Saponification Value: 60 – 75
- Acid Value: ≤ 2.0 mg KOH/g
- Packaging Configurations: 25kg HDPE pails, 200kg UN-approved steel-plastic composite drums, or 1,000kg IBC totes for large-scale industrial compounding plants.
Product Packaging
1. Pharmaceutical Solubilization & Self-Emulsifying Drug Delivery Systems (SEDDS)
In the pharmaceutical sector, over 40% of newly discovered active pharmaceutical ingredients (APIs) suffer from poor water solubility (BCS Class II and IV molecules). Our pharmaceutical-grade Cremophor EL solubilizer for lipophilic drugs is an industry standard for formulating oral, topical, and lipid-based lipid-based delivery vehicles. It effectively reduces interfacial tension, facilitating the spontaneous formation of microemulsions that maximize drug absorption and systemic bioavailability without causing cellular toxicity.
2. Cosmetic Emulsification & Premium Fragrance Solubilizing Systems
Cosmetic formulation chemists utilize our material as a highly efficient non-ionic emulsifier for O/W cosmetic creams and crystal-clear body washes. Thanks to its optimal HLB range (12–14), it can easily solubilize essential oils, hydrophobic fragrances, and oil-soluble vitamins (like Vitamin E acetate) into clear aqueous systems without requiring high alcohol concentrations. Sourcing teams prioritize our low-odor batches to ensure that delicate consumer scent profiles remain pure and unmasked.
3. Agrochemical Formulations & Water-Soluble Pesticide Adjuvants
In agricultural chemistry, achieving uniform field distribution of hydrophobic active molecules is vital for crop protection. Integrating our Cremophor EL pesticide emulsifier concentrate into Emulsifiable Concentrate (EC) or Suspension Concentrate (SC) recipes ensures superior wetting, rapid dispersion upon dilution in hard water, and enhanced foliar penetration. Its natural castor oil backbone provides an excellent eco-toxicity profile, satisfying stringent global agricultural chemical discharge criteria.
FAQ
A: The primary differentiation lies in emulsification stability and chemical composition. Cremophor EL features a complex mixture of hydrophobic ricinoleic acid esters and hydrophilic polyoxyethylene glycols, providing broader compatibility with highly lipophilic molecules. In many self-emulsifying drug delivery systems (SEDDS) and volatile fragrance systems, Cremophor EL forms smaller, more uniform micelle structures than Tween 80, translating to superior clarity and longer emulsion shelf life.
A: This is a natural physical characteristic of high-molecular-weight ethoxylated surfactants and does not represent a quality defect. If the liquid thickens or pastifies, simply store the container in a warm room or apply a heating jacket at 35°C to 45°C (95°F to 113°F) and agitate thoroughly before sampling. Avoid direct open-flame heating to prevent localized overheating and discoloration of the polymer.
A: We provide standard 250g to 500g technical evaluation samples packed in secure HDPE bottles along with a lot-specific refractive index, hydroxyl value, and moisture profile. For commercial scale-up batches, spot stock can be dispatched from our seaport staging yards within 5 to 7 business days of contract finalization.
Related References
Auditing Our Supply Chain: Why Sourcing Directors Choose Us
Global industrial manufacturing requires rigid supply chain continuity, explicit regulatory declaration alignment, and predictable raw material behavior. We protect your plant’s production schedule by acting as an audited, fully transparent supply chain partner.
- Exceptional Low-Temperature Reversibility: If exposed to freezing winter transit conditions, our material may solidify or thicken. However, its complex ethoxylated structure guarantees full reversibility upon mild warming (30°C–40°C) with zero phase stratification, preventing batch loss.
- Comprehensive Regulatory Validation: Sourcing teams can seamlessly request full validation documentation packages, including Polyoxyl 35 Castor Oil USP/NF COA, allergen statements, BSE/TSE-free declarations, and up-to-date MSDS / SDSsheets for smooth international customs clearance.
- Stable Wholesale Pricing Models: Eliminate trading company markups. We provide highly competitive wholesale Cremophor EL pricingstructures with volume-based tier discounts designed to optimize your commercial compounding and manufacturing margins.
- Strategic Staging & Multi-Compounding Logistics: We operate climate-controlled staging zones across major shipping hubs, preventing long-term heat exposure that can accelerate peroxide formation, ensuring a fresh, low-acid-value active surfactant upon delivery.
Manufacturer of Cremophor EL
Achievements
Zhishang Chem is based in Shandong, serves the whole country, faces the world, and is determined to become an excellent supplier and service provider in the chemical industry.
As a top manufacturer of cosmetic raw materials, disinfectants, flavors and fragrances in China, we are committed to producing high-quality products and have won high praise from customers all over the world.
In the next 10 years or even longer, Zhishang will always adhere to the tenet of quality first and reputation first, and devote itself to providing customers with thoughtful and perfect services.
As a professional Cremophor EL manufacturer, Zhi shang Chemical has served more than 6,000 customers around the world. Because of our high-quality products and professional services, we have won high praise from most of our customers.
Service
Pre-Sales Service
* Timely reply and 24 hours online, the professional team will provide you with the most favorable prices and high-quality products.
* The sample supports testing and inspection.
* Each batch of products will be tested to ensure that its quality meets user needs.
*Packaging can also be made according to customer requirements.
*Any inquiries will be answered by our relevant personnel within 24 hours.
*We will provide you with commercial invoice, packing list, packing list, COA, health certificate and certificate of origin if you need it. If your market has other special requirements, please let us know.
Advice on Shipping
1. For products ≤50kg, we recommend using express delivery, which is usually called DDU service (discounted, convenient).
2. For products ≤500kg, we generally recommend air freight, which is usually called FOB, CFR or CIF service (fast and efficient).
3. For products >500kg, we generally recommend shipping by sea, which is usually called FOB, CFR or CIF service (economical, safe).
4. For high-value products, please choose air or express to ensure the safety of product transportation.
Company Info
ZhishangChem company in China that exports chemicals, Cosmetic raw materials, and Intermediates for over 70 countries now.
And a range of 50,000 products with the best quality and competitive price to meet your different purchasing needs.
Cooperation Partner
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