Palmitoylethanolamide (CAS 544-31-0) Manufacturer & Bulk Supplier | Micronized PEA Powder
Name: Palmitoylethanolamide
Cas: 544-31-0
Purity: 99%
MOQ: 1KG
Directory Guidance on Palmitoylethanolamide
Chemical Structure
Basic Info
Palmitoylethanolamide (CAS 544-31-0): High-Purity Lipid Medium for Advanced Dietary Formulations
Palmitoylethanolamide (PEA) is an endogenous fatty acid amide belonging to the N-acylethanolamine molecule class. Naturally occurring in human tissues, mammalian organs, and food sources such as egg yolks, peanuts, and soy lecithin, PEA acts as a key biological lipid mediator interacting with cellular receptors in the endocannabinoid system (ECS) signaling pathways.
In industrial manufacturing, PEA is synthesized via high-precision fatty acid amidation to yield a crystalline powder with exceptional stability. Due to its hydrophobic lipid structure, particle size management—specifically micronization—is critical for enhancing dispersibility and oral absorption. We offer both standard crystalline and ultra-micronized PEA raw material tailored for oral solid dosage forms, softgels, and multi-ingredient wellness blends.
| Melting point | 97-98℃ |
| Boiling point | 461.5±28.0 °C(Predicted) |
| density | 0.910±0.06 g/cm3(Predicted) |
| vapor pressure | 0.45Pa at 20℃ |
| RTECS | ML8950000 |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml). |
| form | White solid |
| pka | 14.49±0.10(Predicted) |
| color | White |
| Water Solubility | 4.01mg/L at 20℃ |
Our production facilities and quality control protocols strictly align with international manufacturing guidelines, ensuring smooth regulatory registration and global compliance for finished brands.
cGMP & ISO 22000 Compliance: Produced under current Good Manufacturing Practices to ensure complete batch traceability and stringent environmental control.
Kosher & Halal Certified: Certified to meet diverse cultural dietary standards globally.
Regulatory Dossier Readiness: Complete technical documentation packages available, including Safety Data Sheets (SDS compliant with GHS standards), Certificate of Analysis (COA), Flowcharts, Residual Solvent Statements, and Allergen Statements.
Non-GMO & BSE/TSE-Free: Verified raw materials free from genetically modified organisms and animal-derived contaminants.
Product Packaging
To ensure that each shipment meets rigid pharmaceutical and nutraceutical standards, our quality unit executes rigorous testing protocols on raw materials, in-process intermediates, and finished product batches.
Assay & Identity Testing: Identified via FTIR (Fourier-Transform Infrared Spectroscopy) and quantified using validated High-Performance Liquid Chromatography (HPLC-UV) to ensure purity consistently meets specification.
Particle Size Distribution (PSD) Analysis: Measured using Laser Diffraction Particle Size Analyzers (e.g., Malvern Mastersizer) to verify micronization parameters (D50 < 10 µm / D90 < 25 µm), ensuring consistent dissolution rates.
Heavy Metals & Trace Contaminant Screening: Analyzed via ICP-MS to guarantee lead, arsenic, cadmium, and mercury levels remain well below international safety thresholds.
Residual Solvent Control: Checked via Gas Chromatography (GC-FID/HS) to confirm compliance with ICH Q3C limits for organic solvents.
Microbiological Testing: Total aerobic microbial count (TAMC), yeast, mold, and pathogens (such as E. coli and Salmonella) are rigorously screened to comply with dietary supplement safety guidelines.
Palmitoylethanolamide serves as a versatile functional raw material across nutraceutical, athletic recovery, and animal health formulations:
Dietary Supplements & Capsule Blends: Utilized as a standalone dietary ingredient or combined with synergistic lipid-soluble compounds (such as luteolin, quercetin, or liposomal curcumin) to support cellular homeostasis.
Sports Nutrition & Physical Recovery Formulations: Incorporated into post-workout recovery products aimed at supporting tissue balance and joint comfort following intense physical exertion.
Functional Tablets & Hard-Gel Capsules: Micronized PEA exhibits favorable bulk density and flowability, making it suitable for direct compression or high-speed automated encapsulation.
Veterinary & Pet Care Products: Formulated into companion animal supplements (chews, pastes) designed to support physiological recovery and comfort.
Formulation & Processing Notes:
Solubility: Insoluble in water; sparingly soluble in ethanol; soluble in hot lipid matrices.
Excipient Compatibility: Emulsifiers (such as lecithin or polysorbates) or medium-chain triglycerides (MCT) can be added to enhance lipid system stability.
FAQ
A: Standard PEA powder possesses a relatively large particle size and low water solubility. Micronization significantly reduces the particle size (typically below 10–20 microns), increasing total surface area. This process enhances intestinal dissolution kinetics and biological uptake without modifying the chemical structure of the molecule.
A: PEA exhibits a melting point between 96°C and 98°C and remains stable under standard processing temperatures. However, exposure to temperatures exceeding 60°C during wet granulation or drying should be monitored to prevent soft agglomeration.
A: The material is packed in 25 kg fiber drums with double PE inner bags. It should be stored in cool, dry conditions (preferably below 25°C) inside sealed containers, shielded from light and excess moisture. Under recommended conditions, the shelf life is typically 24 to 36 months.
Related References
Pubchem-Palmitoylethanolamide
Chemicalbook-Palmitoylethanolamide
Manufacturer of Palmitoylethanolamide
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