Where is the difference between chlorinated gluconate and chlorinated acetate?

At present, chlorhexidine compound preparation (chlorhexidine) has been applied more and more in the field of infection control, which can be used for skin disinfection, hand disinfection, oral mucosa disinfection, preoperative bath, etc. If you look closely at the ingredient list, you find that there are two kinds of Chlorhexidine digluconate and Chlorhexidine Diacetate. What is the difference between these two kinds of chlorhexidine acetate?

1. All chlorhexidine salts

Both are white powder

Chlorhexidine digluconate:Chlorhexidine combines with gluconic acid to form a salt

Chlorhexidine Diacetate:Chlorhexidine combines with acetic acid to form a salt.


2. Prices are different

3. Different solubility

Chlorhexidine digluconate:Low water solubility and high (20%).

Chlorhexidine Diacetate:Fat soluble salt, low water solubility (1.8%), dissolved mainly in alcohol

4. The effect is different

Chlorhexidine digluconate:At low concentration, the disinfection effect and bacteriostatic effect are strong, and the bacteriostatic time is prolonged obviously

Chlorhexidine Diacetate:At low concentration, its disinfection effect and bacteriostatic effect are weak.

5. Excitement

Chlorhexidine digluconate:Less irritant and allergenic

Chlorhexidine Diacetate:There is a certain irritation and allergy to mucous tissue.

In the skin irritation experiment, Chlorhexidine Diacetate was twice as much as Chlorhexidine digluconate. In the sensitization test, Chlorhexidine Diacetate was 3.4 times that of Chlorhexidine digluconate.

6. Recommended by European and American countries

Due to the difference of safety and disinfection effect, most of the products of Chlorhexidine digluconate are used in European and American countries, and the research reports in recent ten years also focus on the use of Chlorhexidine digluconate

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