Climbazole CAS 38083-17-9 Manufacturer & Supplier | High Purity ≥99% | Zhishang Chem
Name: Climbazole
Cas: 38083-17-9
Purity: 99%
MOQ: 1KG
Directory Guidance on Climbazole
Chemical Structure
Basic Info
Climbazole (CAS Registry Number: 38083-17-9; IUPAC Name: 1-(4-chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutan-2-one) is a high-performance topical antimicrobial active agent belonging to the imidazole functional class. Recognized globally in cosmetic science, it serves as an effective anti-dandruff ingredient for modern hair care and scalp conditioning applications.
Manufactured under precision process controls by Shandong Zhishang Chem Co., Ltd., our cosmetic-grade Climbazole delivers high crystalline assay purity (≥ 99.0%), thermal stability during liquid processing, and compatibility with primary surfactant systems. It is widely selected by global personal care brand formulators for premium clarifying shampoos, scalp serums, and rinse-off hair treatments.
| Melting point | 96-100°C |
| Boiling point | 447.5±40.0 °C(Predicted) |
| density | 1.17±0.1 g/cm3(Predicted) |
| vapor pressure | 0.001Pa at 25℃ |
| refractive index | 1.54 |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Insoluble in water |
| form | Solid |
| pka | 5.66±0.22(Predicted) |
| color | White to Almost white |
| Water Solubility | 58mg/L at 25℃ |
International cosmetic regulatory authorities enforce clear safety and quality standards for hair care ingredients. Shandong Zhishang Chem operates in compliance with international guidelines to support customer product registration:
ISO 9001:2015 Quality Certification: Standardized control across synthesis, crystallization, micronization, and cleanroom packaging lines.
Cosmetic Raw Material GMP Standards: Environmentally controlled processing environments minimizing particulate and cross-batch contamination.
REACH Dossier Compliance: Regulatory technical dossiers provided for European Union cosmetics manufacturers and distribution partners.
Global Safety Limits Alignment: Produced to align with international cosmetic raw material safety standards (such as EU SCCS guidelines) for both rinse-off and leave-on scalp formulations.
Product Packaging
To maintain batch-to-batch stability and prevent formulation turbidity, every production lot of Climbazole undergoes self-inspection prior to issuing the Certificate of Analysis (COA):
HPLC Assay Profiling: Quantitative analysis ensuring active purity remains ≥ 99.0% while monitoring trace organic impurities.
Residual Solvent Screening (GC Analysis): Verification of volatile organic solvent limits to meet cosmetic ingredient safety specifications.
Melting Point Range Verification: Confirms uniform crystalline integrity, ensuring complete dissolution during shampoo hot-mix phase processing.
ICP-MS Heavy Metal & Microscopic Testing: Rigorous screening for heavy metals (Pb, As, Hg, Cd) to guarantee compliance for daily consumer use.
Climbazole works by selectively inhibiting surface microorganisms (such as Malassezia furfur) on the scalp, helping reduce flaking and itchiness while remaining gentle on the hair shaft:
Rinse-Off Anti-Dandruff Shampoos: Functions as the key active agent (typical usage level: 0.5% to 2.0% in rinse-off bases) to keep scalps clear while maintaining foam stability and conditioning benefits.
Leave-On Scalp Serums & Tonics: Formulated into lightweight leave-on scalp conditioners (typical usage level: up to 0.5%) for long-lasting scalp protection without greasy residues.
Conditioning Hair Treatments & Masks: Compatible with cationic conditioning agents and non-ionic polymers, delivering scalp clarity alongside hair smooth feel.
Specialized Body Cleansers: Utilized as a broad-spectrum topical active in cleansing washes and personal hygiene bar soaps.
FAQ
A: Climbazole has low direct water solubility. It should be pre-dissolved in the surfactant phase, organic solvents (such as alcohol or glycols), or non-ionic fragrance solubilizers before water addition. Gentle heating to 50°C–60°C during phase prep speeds up complete dissolution and prevents recrystallization.
A: Store Climbazole powder in sealed original containers in a cool, dry, well-ventilated space below 30°C, away from direct sunlight and moisture. Sealed shelf life is 24 months under these conditions.
A: Each commercial order includes a batch Certificate of Analysis (COA), GHS-compliant Safety Data Sheet (SDS), Technical Data Sheet (TDS), and REACH documentation upon request.
Related References
Pubchem-Climbazole
Chemicalbook-Climbazole
Manufacturer of Climbazole
1. For products ≤50kg, we recommend using express delivery, which is usually called DDU service (discounted, convenient).
2. For products ≤500kg, we generally recommend air freight, which is usually called FOB, CFR or CIF service (fast and efficient).
3. For products >500kg, we generally recommend shipping by sea, which is usually called FOB, CFR or CIF service (economical, safe).
4. For high-value products, please choose air or express to ensure the safety of product transportation.
